Results published in the most recent online issue of the Journal of American Academy of Dermatology showed that treatment with Sculptra® Aesthetic (injectable poly-L-lactic acid) was significantly more effective than a human-derived collagen treatment CosmoPlast® in correcting shallow to deep nasolabial fold (NLF) wrinkles (smile lines). In addition, this study demonstrated that the effect in correcting the NLF wrinkles with Sculptra Aesthetic can last for up to 25 months.

A total of 233 patients of ages ranging from 26 to 73 years were randomized to receive injections of either Sculptra Aesthetic (N=116) or CosmoPlast (N=117) (standard of care at study initiation) into the left and right nasolabial folds at 3-week intervals for up to a maximum of four treatments and followed for 13 months after the final treatment. Treatment with Sculptra Aesthetic resulted in significantly (P<0.001) higher scores than CosmoPlast on the Wrinkle Assessment Scale, a validated photographic measurement tool which is used to assess the NLF wrinkles at week 3, and months 3, 6, 9, and 13 during the follow up phase of the study.

The Sculptra Aesthetic patients were followed for an additional 12 months. Sculptra Aesthetic treatment effects were maintained up to 25 months after the last treatment session, while the human-derived collagen was effective up to 3 months.

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[Source: Medical News Today/Sanofi Aventis]