For the estimated 7% of adults in the United States who suffer from atopic dermatitis, their burden often extends beyond the immediate dermatologic effects of the disease. A wide range of comorbid conditions has been observed in this patient population, including asthma, cardiovascular disease, diabetes, and autoimmune disease, as well as psychological disorders such as depression and anxiety.

In addition, results of emerging research highlight the association of skin pain with atopic dermatitis, including recent studies reporting skin pain in 43% to 78% of patients with eczema.