“If you’re looking for a face-lift in a bottle, you probably won’t find it in over-the-counter wrinkle creams. The benefits of these products are usually only modest at best,” write the staff at the Mayo Clinic, America’s best hospital according to the US News & World Report.

No matter how expensive the price tag or how exotic ingredients may seem, any skin care product that doesn’t need a doctor’s prescription is not required to undergo scientific research to prove its effectiveness.

Since they are not classified as drugs, Food and Drug Administration (FDA) law “does not require cosmetic products to have FDA approval before they go on the market.”

As such, it’s unlikely that the lotions, creams, sprays, and ointments you’re putting on your face have undergone any type of scientific research, much less a study that proves their effectiveness in reducing wrinkles or boosting skin health (unless you got them from a doctor).

That said, some products are better than others. According to the Mayo Clinic, the following ingredients may help reduce the appearance of certain aging hallmarks, though the University of Maryland points out the evidence is scant:

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