The recently released AcneDX Genetic Test for Antibiotic Response, from DermaGenoma Inc (Irvine, Calif) helps guide physicians to assess the antibiotic susceptibility of the bacteria, propionibacterium acnes (P. acnes), involved in the pathogenesis of acne. Using the test, a doctor may be able to improve the acne in a quicker and safer manner, according to a press release from the company.
While dermatologists often prescribe antibiotic treatment for acne, moderate to severe acne requires several months of therapy prior to improvement. Unfortunately, patients often observe little or no visual improvement due to the drug resistance of the acne bacteria, propionibacterium acnes (P. acnes). The AcneDX Genetic Test for Antibiotic Response may help find the right treatment. It is most appropriate for patients who plan to undergo systemic antibiotic therapy for their acne.
“Prolonged use of systemic antibiotics promotes bacterial resistance throughout a patient’s bacterial flora. This decreases the effectiveness of these antibiotics for future infections,” says Alan Shalita, MD, Chairman of the Department of Dermatology at SUNY Downstate. “Selecting and using the most effective treatment for acne can improve the outcome and reduce the psychosocial impact on patients.”
The AcneDX Genetic Test for Antibiotic Response provides information on the presence of specific variations in the propionibacterium acnes (P. acnes) bacteria genes.
For example, a patient who tests positive for the P. acnes bacteria gene variants has up to approximately 80% chance of antibiotic treatment failure. (The predictive value of the AcneDX Test is dependent on the genetic variation and antibiotic agent used; therefore, individual results may be substantially less then 75%.)
A patient who tests negative for the P. acnes bacteria gene variants has up to approximately 75%* chance of antibiotic treatment success.
Individuals who test positive for the P. acnes bacteria gene variants should be advised that they are at a high risk for antibiotic treatment failure. These individuals may wish to consult with a dermatologist who can develop a more effective treatment plan for their acne.
[Source: DermaGenoma Inc/Businesswire]