Treating children with severe atopic dermatitis remains a challenge because there are so few effective and approved therapies. But there is hope that pipeline therapies, including Janus kinas (JAK) inhibitors and a monoclonal antibody against IL-31 receptor for treatment of itch may address some needs among severely impacted children, researchers write in the online May issue of Current Allergy and Asthma Reports.

The researchers reviewed what is known about severe atopic dermatitis in children and identified gaps in treatment and knowledge.