Scientists working on a treatment for babies born with cleft palates have made a promising breakthrough, and the first clinical trials are planned for early next year. The preliminary results on a hydrogel material studied using the UK-based Science and Technology Facilities Council’s ISIS neutron source show treatment for severe cleft palates could be carried out without the need for complex surgery.
Cleft palates are currently repaired by surgically repositioning the available palatal mucosa, the tissue structure at the roof of the mouth, in order to cover the gap in the palate. However, if the cleft defect is too wide, there may be insufficient local tissue available to close the gap without undertaking quite radical surgery. It is these severe cases that can cause future complications for infants as they develop into adults—particularly with speech and facial growth problems.
A team of researchers at the University of Oxford, the John Radcliffe Hospital in Oxfordshire, and the Georgia Institute of Technology in the United States has used ISIS to look at hydrogel on the molecular level to try and gather enough information to develop materials that could be used for a potential new treatment.
“ISIS provided us with the high level of structural detail we needed to assess the new material. It gives unique and accurate results that we can’t get with any other technique,” says Professor David Bucknall from the Georgia Institute of Technology.
The new potential treatment for these severe cases involves inserting a small plate made of an anisotropic hydrogel material (similar to that used in contact lenses) under the mucosa of the roof of the patient’s mouth.
The hydrogel gradually expands as fluid is absorbed, encouraging skin growth over and around the plate—a process known as "tissue expansion." When sufficient skin has been generated to repair the palatal cleft, the plate is removed and the cleft is repaired by using this additional tissue. The success of the preliminary results of self-inflating anisotropic hydrogel tissue expanders mean clinical trials in this area are expected to take place early in 2011.
“Babies born with cleft palates usually have problems feeding, and may have speech difficulties in later life, as well as issues with their hearing, dentition, and facial growth,” says Marc Swan, a plastic surgeon at the John Radcliffe Hospital in Oxford and the instigator of the study. “The severest cases often have the least favourable outcomes, and unfortunately these are the most challenging children to treat surgically.”
[Source: Science and Technology Facilities Council]